ADDA - Automatic Domain Decomposition Algorithm

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ADDA - Automatic decomposition of domain families


This is a web interface for ADDA, an automatic algorithm for domain decomposition and clustering of all protein domain families. We use alignments derived from an all-on-all sequence comparison to define domains within protein sequences based on a global maximum likelihood model.

ADDA is used to build PFAM-B families - the PFAM server is now the best location for browsing latest domain definitions. The latest ADDA domain definitions can be downloaded from here. This server is not being updated and is preserved for historical purposes.


Search for a protein by identifier, accession number or by its sequence,
Search for a domain family,
Browse the domain families,
Go to quality control and statistics,
Go to the download area (academic licence).


Heger A, Holm LU (2003) Exhaustive enumeration of protein domain families.
J Mol Biol 328(3):749-67.

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Help & Other Resources



The Holm Group
Services & Tools


A collection of Frequently Asked Questions about ADDA


Selected Links



ADDA Support Team
Andreas Heger
Liisa Holm
Chris Wilton
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